Staff Scientist - Analytical Pharmacology Core Facility

Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Beckman Research Institute of City of Hope is looking for a talented Staff Scientist to perform several functions as a member of the Analytical Pharmacology Core Facility. Your primary role will include operation of the liquid chromatography tandem mass spectrometry (LC-MS/MS) instrumentation available in the core. These efforts will include not only operating the instrument but also assay development, sample preparation, calibration, data analysis, data management/backup and routine maintenance/trouble shooting. In addition, you will assist the director with the development and validation of new analytical methods for the quantitative analysis of large and small molecules in support of pharmacokinetic and biomarker investigations.

As a successful candidate, you will:

• Develop and apply new and established LC-MS/MS and ICP-MS analytical methods.
• Perform data analysis, maintain records, report analytical results, prepare Standard Operating Procedures (SOPs) for sample preparation and analysis, and assist in manuscript preparation for publications.
• Perform preventative maintenance and troubleshooting of problems with laboratory equipment.
• Consult with core users regarding appropriateness of analytical methods and experimental design
• Coordinate sample collection and batch preparation together with other lab staff.
• Participate in and present findings at weekly lab meetings and provide cross-training to other lab members.

Your qualifications should include:

• Ph.D., Pharm.D. or M.D/Ph.D. degree in Pharmacology, Analytical Chemistry, Life Sciences or related discipline with a background within preclinical and clinical pharmacokinetic studies. A Master's degree with a minimum of 3 years of experience in an analytical laboratory will also be considered.
• Previous experience using LC-MS/MS instrumentation for quantitative analysis of large and small molecules required.
• Experience with Waters and/or AB Sciex instruments is particularly desirable.
• Experience with ICP-MS analyses using an Agilent system is also desirable.
• Other important skills include knowledge of analytical chemistry and experience with instrument controller software programs, like MassLynx and Analyst.
• Knowledge of the principles of quantitative analysis and familiarity with the FDA's Biomedical Method Validation Guidance for Industry are also preferred.
• Strong interpersonal, documentation, and organizational skills, and a commitment to providing high-quality analytical chemistry services for users of the core facility are essential.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

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