Senior Associate Scientist, Research Analytics

We are looking for a highly motivated Senior Associate Scientist to join our Research Analytics group and contribute to the further exploration of RNAi therapeutics. The successful candidate will help to support siRNA design and discovery through implementation of existing and novel analytical methods. Areas of focus include understanding in vivo/in vitro metabolism of siRNA in relevant tissue and cell types using established analytical methods, exploring stability of novel siRNA conjugates for targeted delivery, and developing robust analytical methods for early CMC work.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities:

• Utilize analytical techniques such as hybridization ELISA, MSD, ELISA, HPLC, Gel Electrophoresis, and Western Blot to support pharmacokinetic and stability analysis of siRNA.
• Effectively troubleshoot and optimize assay conditions and sample preparation protocols to improve assay sensitivity, specificity, and reproducibility.
• Analyze and interpret ligand binding assay data to provide PK insights to present to team members.
• Improve upon and/or develop new methods and automation for analysis of siRNA accumulation and stability.
• Collaborate closely with cross-functional teams including PK/PD, bioanalytical, and discovery groups to integrate assay results.

Qualifications:

• Bachelor's or Master's degree in Chemistry, Biochemistry, or a related field.
• 3+ years of work experience, preferably in an industrial setting.
• Attention to detail with a commitment to accuracy and quality in experimental execution and design is highly preferred.
• Hands-on experience with ligand binding assays (e.g., hybridization ELISA, MSD, ELISA) is highly preferred.
• Familiarity with bioanalytical techniques and instrumentation for PK analysis is preferred.
• Experience with assay optimization, validation, and troubleshooting is preferred.
• Familiarity with instrumentation such as HPLC, Gel Electrophoresis, etc. is preferred.
• Ability to function within a highly interdisciplinary environment is a must.
• Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.
• Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.