Principal Scientist, In Vivo Oncology

The Extracellular Targeted Cancer Therapeutics (ETCT) Biology Unit within the Oncology Research Unit is seeking an experienced In Vivo Principal Scientist to support a growing portfolio of targeted Oncology assets. The successful applicant will have prior experience designing and executing critical path in vivo

experiments in support of the development of novel cancer therapies such as antibody-drug conjugates (ADCs) and T cell engagers (TCEs).

As an In Vivo Principal Scientist in ETCT, your responsibilities will be to:

• Work within a dynamic environment as a member of a global matrix team to design and execute in vivo pharmacology experiments in disease-relevant models to evaluate the effects of targeted biologics in the Oncology portfolio.
• Work independently to design and implement new murine tumor models to improve in vivo pharmacology and/or efficacy outcomes.
• Write IACUC protocols and interface with appropriate GSK ethics & compliance groups supporting animal models.
• Care for and handle laboratory animals, ensuring their well-being and compliance with ethical standards and regulatory guidelines in animal research.
• Administer experimental compounds to animals via various routes (e.g., oral, intravenous, intraperitoneal, subcutaneous) while following established protocols.
• Collect data on the effects of test compounds including tumor growth inhibition, PK/PD parameters, and safety endpoints.
• Analyze data from in vivo pharmacology studies, perform statistical analyses with appropriate software to draw conclusions and clearly communicate study outcomes to cross-functional scientific teams.
• Maintain detailed and accurate records of experiments, procedures, and results.
• Collaborate with multidisciplinary teams, including chemists, biologists and toxicologists, to contribute to the drug development process.
• Operate and maintain specialized laboratory equipment used in in vivo experiments, such as digital calipers, study data collection software systems, and physiological monitoring devices.
• Prepare reports and presentations summarizing findings for internal stakeholders and regulatory submissions.
• Build communication networks across the Oncology Research Team and broader organization.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• BS with at least 3 years of relevant oncology in vivo murine tumor model experience in industry or academia.
• 3+ years of experience in design, conduct and analysis of data from in vivo pharmacology studies.
• At least 5 years of experience in mouse handling, dosing, caliper measurements, and tissue sampling skills enabling the ability to independently conduct tumor model studies assessing tumor growth, efficacy and PK/PD of biologics in xenograft murine models.
• Minimum of 3 years of experience with ex vivo tissue processing and aseptic tissue culture technique with human and murine primary cells and cancer cell lines.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• MS in Cell Biology, Pharmacology, Immunology or related fields with 3+ years of pharmaceutical/biotechnology industry research and leadership experience.
• Expertise in techniques including cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation, and measurements.
• Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations.
• Ability to lead from the bench in problem solving and the development of innovative solutions.
• Data analytical skills using Prism Graph Pad or other related software.
• Experience with translational Oncology models and the use of humanized transgenic murine models (e.g. NSG mice with PBMC-based reconstitution of a human immune system).
• Experience with the design and testing of biologics assets using in vivo Oncology models including T cell engaging bispecific antibodies (TCEs) and antibody drug conjugates (ADCs).
• Direct supervisory and/or management experience for a range of in vivo scientists and technical support staff.
• Excellent communication skills with the ability to work effectively in a dynamic and flexible team environment.
• Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods and interpretation.
• Independence, problem-solving abilities, self-motivation, resourcefulness, and the ability to manage multiple priorities in a matrix environment.

The position is available in Upper Providence, PA, USA

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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